Description

What is LGD-4033?

LGD-4033, also known as Ligandrol, is a Selective Androgen Receptor Modulator (SARM) originally developed by the company Ligand Pharmaceuticals.

SARMs like LGD-4033 are used in bodybuilding as an alternative to anabolic steroids. Ligandrol has a high binding affinity for androgen receptors and is selective—meaning it only binds to receptors found in muscle and bone tissue.

It was originally developed to treat muscle-wasting conditions (like muscular dystrophy). LGD-4033 offers effects similar to anabolic steroids—muscle growth, joint and tendon support—but with far fewer unwanted side effects such as high blood pressure, hair loss, gynecomastia, acne, testicular atrophy, prostate enlargement, or liver toxicity.

What kind of results can you expect from LGD-4033?

An 8-week cycle of Ligandrol, combined with proper nutrition and training, typically results in a 3–5 kg increase in muscle mass.

Is LGD-4033 suitable for women?

No. Ligandrol has androgenic effects and is not recommended for women who want to avoid developing masculine traits. For women, Ostarine is a better alternative, as it lacks masculinizing effects.

Can LGD-4033 be taken year-round?

No. It must be cycled. A minimum 4-week break between Ligandrol cycles is recommended.

How long does a Ligandrol cycle last?

Typically 6 to 8 weeks.

What is the correct dosage?

• Low dose: 1 mg/day
• Moderate dose: 5 mg/day
• High dose: 8–10 mg/day (higher risk of side effects in this range)

Does it affect the liver?

No. LGD-4033 is not methylated, so it does not cause liver toxicity. No liver protection is needed.

Best time to take Ligandrol?

Timing doesn’t matter—LGD-4033 has a long half-life of 24–36 hours, so once a day is sufficient.

Does it impact estrogen levels?

No. Ligandrol, like other SARMs, does not aromatize, meaning it does not increase estrogen levels.

Can it increase blood pressure?

No.

Should it be taken on an empty stomach?

It doesn’t matter—bioavailability is the same with or without food.

Are there any other side effects?

LGD-4033 may cause a temporary reduction in natural testosterone production, especially with long cycles or high doses. Testosterone levels usually normalize within 1–2 weeks after stopping.

Is post-cycle therapy (PCT) necessary?

To minimize testosterone suppression at the end of longer or higher-dose cycles, many users take a SERM like Toremifene or Raloxifene as part of their PCT.

Can it help strengthen joints or aid injury recovery?

Yes, but Ostarine is generally more effective for joint support and injury rehabilitation.